Somatic STK11 and Concomitant STK11/KRAS Mutational Frequency in Stage IV Lung Adenocarcinoma Adrenal Metastases
نویسندگان
چکیده
منابع مشابه
Stage IV Primary Vaginal Leiomyosarcoma with Lung and Breast Metastases.
BACKGROUND: Reproductive tract sarcomas metastasizing to the breast are uncommon. To our knowledge, metastasis of vaginal leiomyosarcoma to the breast has not been previously reported in the literature. CASE REPORT: We present the first report of a FIGO stage IV primary vaginal leiomyosarcoma with metastases to the lung and left breast. Treatment included neoadjuvant chemotherapy followed by s...
متن کاملLung Adenocarcinoma with Pulmonary Miliary Metastases and Complex Somatic Heterozygous EGFR Mutation
The pretreatment detection of an activating mutation of EGFR is now routinely performed in metastatic nonsquamous non-small cell lung cancer (NSCLC). The therapeutic impact of such a detection is major, as patients with advanced NSCLC exhibiting a mutation of exon 19 or 21 will benefit from EGFR-tyrosine kinase inhibitors (TKI). The presence of an EGFR resistance mutation, such as T790M in EGFR...
متن کاملOmental metastases from primary lung adenocarcinoma.
Lung cancer represents one of the most common malignant diseases worldwide and the major cause of cancer related deaths accounting for 25% of all cancer deaths and with a 5 years survival rate of 10-20%.1-4 Approximately 40-50% of the patients with lung cancer at the time of diagnosis present with metastatic disease.1,2,4,5 The most common sites of metastatic spread include the liver, brain, ad...
متن کاملThe transcriptional landscape and mutational profile of lung adenocarcinoma.
All cancers harbor molecular alterations in their genomes. The transcriptional consequences of these somatic mutations have not yet been comprehensively explored in lung cancer. Here we present the first large scale RNA sequencing study of lung adenocarcinoma, demonstrating its power to identify somatic point mutations as well as transcriptional variants such as gene fusions, alternative splici...
متن کاملStaining pattern of type IV collagen and prognosis in early stage adenocarcinoma of the lung.
AIMS To examine the prognostic value of basement membrane expression in early stage adenocarcinoma of the lung. METHODS Using antibodies to type IV collagen, basement membrane expression at the tumour-stromal border was immunohistochemically analysed in 30 patients with early stage adenocarcinoma of the lung (pstage I and pstage II). Two patterns of staining for type IV collagen were observed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2015
ISSN: 1556-0864
DOI: 10.1097/jto.0000000000000391